Open Access Pub publishes peer-reviewed, free-to-read open-access articles. Showing
articles matching Allele — open any to read the full text,
or download the PDF or XML.
Dec 2019 DOI 10.14302/issn.2326-0793.jpgr-19-3114
Benjamin OllomoCorresponding author
Background During the last two decades, the polymorphism of Angiotensin-Converting Enzyme (ACE) gene has been extensively studied among different human populations. In humans, several studies have shown the relationship between this polymorphism and the risk of many serious diseases with a heavy bur…
Aug 2019 DOI 10.14302/issn.2572-3030.jcgb-19-2597
Oluwafemi Oyamakin S.Corresponding author
Department of Statistics, University of Ibadan, Nigeria
In other to present a series of stochastic models from population dynamics capable of describing rudimentary aspects of genetic evolution, we studied two-allele Wright–Fisher and the Moran models for evolution of the relative frequencies of two alleles at a diploid locus under random genetic drift i…
Mar 2017
Mats RembergerCorresponding author
This article examines how HLA‑DRB1 allele mismatching influences outcomes after hematopoietic stem cell transplantation. It reviews graft‑versus‑host disease risk, engraftment, and survival metrics in the context of donor matching strategies. The findings support careful allele‑level typing to optim…
Feb 2025 DOI 10.14302/issn.2326-0793.jpgr-25-5405
Ming-Fen HoCorresponding author
Alcohol use disorder (AUD) is the most prevalent substance use disorder. Excessive alcohol consumption leads to a range of health issues. We set out to identify inflammatory markers linked to alcohol consumption, which might ultimately offer novel insight into genetic underpinnings and have implicat…
May 2020 DOI 10.14302/issn.2575-7881.jdrr-20-3343
Amged Hussen AbdelrhmanCorresponding author
Background Anemia of chronic disease is anemia found in certain chronic disease states, is typically marked by the disturbance of iron homeostasis or hypoferremia. Chronic renal failure is currently known as Chronic Kidney Disease (CKD) or Chronic Renal Insufficiency (CRI) implies long-standing, pro…
Mar 2020 DOI 10.14302/issn.2374-9431.jbd-20-3195
E.G SergeevaCorresponding author
FIRST St. Petersburg state medical University named after academician I. P. Pavlov
Purpose The goals of the present study were to assess the genotypic and allelic distribution of Bsm-I (rs1544410) and Apa-I (rs7975232) polymorphisms of the vitamin D receptor (VDR) gene in coronary artery disease (CAD) patients in comparison to control patients of the same age without CAD and to de…
Mar 2020 DOI 10.14302/issn.2575-1212.jvhc-20-3234
Fabrizio di VirgilioCorresponding author
Aim of the Research The aim of this study is to analyze a group of dogs of different breeds affected by osteosarcoma (OSA), to document any prevalence of this primary bone neoplasia in breeds that are phylogenetically close and to help with further research human medicine, as a model of study for pr…
Mar 2020 DOI 10.14302/issn.2694-1198.jge-20-3206
A.N. VolobuevCorresponding author
On the basis of Hardy – Weinberg’s law the problem of inbreeding in a family tree and a population was investigated. With use of an inbreeding factor are received the discrete equation for a family tree and differential equation for a population. The numerical solution of the differential equation f…
Dec 2019 DOI 10.14302/issn.2694-1198.jge-19-3079
A.N. VolobuevCorresponding author
The problem of natural selection against recessive homozygotes in a population is investigated. It is shown that natural selection of mutant alleles linked with the Х-chromosome in a population at women is described by the nonlinear differential equation of the third order. The order of the differen…
Jun 2019 DOI 10.14302/issn.2374-9431.jbd-19-2788
E.G. SergeevaCorresponding author
Purpose The goal of this study is to determine the association of L162V polymorphism of PPAR-alpha gene, A603G polymorphism of tissue factor gene and the risk of coronary heart disease development in Russian population. Materials and Methods A clinical and genetic study of 414 patients with CHD an…
Feb 2019 DOI 10.14302/issn.2379-7835.ijn-19-2585
Di-Yun ChenCorresponding author
With the possibility of the Water-Energy-Food (WEF) Nexus since a long time back, overlooked interlinkages between WEF are getting the chance to be indisputable. Nonetheless, agriculture is responsible for quite a bit of fresh water over-use. Food production further effects the water and energy sect…
Jun 2017 DOI 10.14302/issn.2576-9359.jot-17-1603
Carlotta CapraraCorresponding author
Single-nucleotide polymorphisms (SNPs) in genes involved in immune responses and in the pharmacokinetics/pharmacodynamics of immunosuppressive drugs influence transplant outcomes of patients receiving the same immunosuppressive therapy. The aim of our preliminary study was to determine the SNPs prof…
Jun 2016
Arup Ratan BandyopadhyayCorresponding author
Earlier studies reported significant association of obesity, hypertension and Type2 Diabetes Mellitus (T2DM). Genetic and many disease-associated alleles have been identified through GWAS and applied to T2DM and indicated roles of renin-angiotensin system (RAS) in insulin signaling pathway and insul…
Feb 2016 DOI 10.14302/issn.2374-9431.jbd-15-890
Norman E. BurokerCorresponding author
Purpose Signal Transducer and Activator of Transcription 4 (STAT4) is important for signaling by interleukins (IL-12 and IL-23) and type 1 interferons and has been found to have several simple nucleotide polymorphisms (SNPs) associated with human disease. STAT4 SNPs were computationally examined wit…
Feb 2016 DOI 10.14302/issn.2326-0793.jpgr-15-889
Norman E. BurokerCorresponding author
Purpose The endothetal Per-Arnt-Sim (PAS) domain protein 1 (EPAS1) gene which encodes hypoxia-inducible-factor-2 alpha (HIF2a) is a transcription factor that is involved in the response to hypoxia. EPAS1 has been found to have four (rs56721780, rs6756667, rs7589621, rs1868092) simple nucleotide poly…